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Gene Expression across Normal and Tumor tissue
 
 
 
 
 
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  Analysis >> epidermal growth factor receptor (EGFR)
 
 The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors: EGFR, ERBB2, ERBB3, and ERBB4. Mutations and over-expression of EGFR are frequently observed in lung, colorectal, and brain tumors. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Iressa (gefitinib), erlotinib, and lapatinib are examples of small molecular kinase inhibitors targeting EGFR and cetuximab (Erbitux) and panitumumab are examples of monoclonal antibody inhibitors.

1. The pattern of EGFR in diverse tumor and normal tissues (U133Plus2 data set)

2. The pattern of EGFR in diverse tumor and normal tissues (U133A data set)

 Again, the over-expression of EGFR in a subset of glioma and lung cancer patients are clearly demonstrated in both figures (U133Plus2 and U133A).

3. The pattern of EGFR in diverse cancer cell lines (U133Plus2 data set)

4. The pattern of EGFR in diverse cancer cell lines (U133A data set)

 And the EGFR over-expression is recapitulated in a subset of glioma, breast, and lung cancer cell lines (3 and 4).

Data Summary
 • Data sets
  - U133Plus2 : 306
- U133A : 241
 • Samples
  - U133Plus2 : 24,300
- U133A : 16,400
 • Probes
  - U133Plus2 : 54,613
- U133A : 22,215
 
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