Introducing the new GENT, GENT2

A huge amount of public data has accumulated since the release of GENT.
That's why we developed GENT2, a quantitative and qualitative upgrade of the GENT system.

GENT2 Construction and content

The GENT2 database provides the following five functions: 1) a landscape of gene expression profile across 72 normal and tumor tissues, 2) cancer subtype profiling, 3) statistical significance of gene expression difference between normal and tumor samples, 4) a prognostic value of gene expression, and 5) meta-survival analysis.

GENT2 Features

GENT2 contains more than 68,000 samples and has several new useful functions. First, GENT2 now provides gene expression across 72 different tissues compared to 57 in GENT. Second, with increasing importance of tumor subtypes, GENT2 provides an option to study the differential expression and its prognostic significance based on tumor subtypes. Third, whenever available, GENT2 provides prognostic information of a gene of interest. Fourth, GENT2 provides a meta-analysis of survival information to provide users more reliable prognostic value of a gene of interest.

Database description

GENT2 contains more than 44,000 (U133Plus2; 887 datasets) and 23,000 (U133A; 358 datasets) samples.
A larger number of samples were added to the original GENT, and over 380 datasets were added for the U133Plus2 platform.

Tissue- and cell line-wide expression profile comparing normal and tumor samples.

Subtype profiling with survival analysis

GENT2 provides the expression profiling of subtypes of the selected tissue. In addition, it provides results of a statistical test (ANOVA or t-test) and survival analysis on the subtype.

Meta-survival analysis

Confirming the prognostic relevance of a gene is important for its application in the clinical field.
Hence, we adopted a meta-survival analysis into GENT2, providing reliable prognostic power estimated by synergetic effect across many independent reports.

GENT2 has many useful features

Many databases have been developed that show gene expression of cancer samples. However, GENT2 has many useful features such as subtype analysis and meta-survival analysis, which are not available in other databases.

GENT2 has many useful features such as subtype analysis and meta-survival analysis, which are not available in other databases. In addition, an intuitive and user friendly interface is another advantage of GENT2